The game, created by the brand's in-house advertising department Specsavers Creative, features a man who mistakes a kitchen for a sauna and is chased through a hotel by an angry chef.
Graham Daldry, creative director at Specsavers Creative, said: "Gamification gives our memorable TV commercials life beyond the TV screen while providing an entertaining and highly effective way for consumers to engage with our popular advertising."
The MSN takeover will see the homepage covered in steam as a man in a towel walks across the screen, with the steam then clearing to reveal the "naked hero" with only a "call to action" button covering his modesty.
Viewers can click on the button to play the "sauna" TV ad and launch the "angry chef" game.
During the game players have to jump over obstacles, pick up items and avoid food being thrown at them by the angry chef as they try to reach the safety of the sauna.
Specsavers will seek to encourage competition by allowing Facebook users to share their score with friends.
Follow Matthew Chapman at @mattchapmanUK